Research Group Manolikakes

Publications

from the Manolikakes Lab


Publications

2024

95. Merging Cobalt-Catalyzed C-H Activation with the Mannich Reaction: An Efficient and Modular Approach to a-Substituted Sulfonamides, O. Olu-Igbiloba, H. Sitzmann, G. Manolikakes, Preprint on posted on ChemRxiv, DOI: 10.26434/chemrxiv-2023-f7j1v-v2

94. Brønsted-Acid Catalyzed Diastereoselective Synthesis of Spiroisoindolinones from Enamides, M. Halaczkiewicz, A. Maraj, H. Kelm, G. Manolikakes, Org. Lett. 2024, 26, 2321-2325. (Preprint posted on ChemRxiv)

2023

93. Glutathione kinetically outcompetes reactions between dimedone and a cyclic sulfenamide or physiological sulfenic acids, E. Bischoff, L. Lang, J. Zimmermann, M. Luczak, A. M. Kiefer, G. Niedner-Schatteburg, G. Manolikakes, B. Morgan, M. Deponte*, Free Radic. Biol. Med. 2023, 208, 165-177.

92. Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome, C., H. P. Huynh Phuoc, O. Awad, B.h S. Parmar, N. Hellmuth, U. Heinicke, S. Amr, J. Grimmer, D. Sürün, K. Husnjak, M. Carlsson, J. Fahrer, T. Bauer, S.-C. Krieg, G. Manolikakes, K. Zacharowski, D. Steinhilber, C. Münch, T. J. Maier, J. Roos*, Cell Chem. Biol.2023, published online, DOI: 10.1016/j.chembiol.2023.06.017.

91. Supporting Sustainability of Chemistry by Linking Research Data with Physically Preserved Research Materials, C.-L. Lin, P.-C. Huang, S. Gräßle, C. Grathwol, P. Tremouilhac, S. Vanderheiden, P. Hodapp, S. Herres-Pawlis, A. Hoffmann, F. Fink, G. Manolikakes, T. Opatz, A. Link, M. M. B. Marques, L. J. Daumann, M. Tsotsalas, F. Biedermann, H. Mutlu, E. Täuscher, F. Bach, T. Drees, S. Neumann, N. Jung*, S. Bräse*, preprint on ChemRxiv, Jul 04, 2023. DOI: 10.26434/chemrxiv-2023-2dd4c.

90. Palladium-Catalyzed Enantioselective Three-Component Synthesis of alpha-Arylglycine Derivatives from Glyoxylic Acid, Sulfonamides and Aryl Trifluoroborates, B. Jakob, N. Schneider, L. Gengenbach, G. Manolikakes, Beilstein J. Org. Chem.2023, 19, 719-726 (Part of the thematic issue Catalytic multi-step domino and one-pot reactions; Preprint posted on ChemRxiv).

89. Palladium-Catalyzed Asymmetric Three-Component Reaction between Glyoxylic Acid, Sulfonamides and Arylboronic Acids for the Synthesis of alpha-Arylglycine Derivatives, B. Jakob, A. M. Diehl, K. Horst, H. Kelm, G. Manolikakes, Front. Chem. 2023, accpeted article. (Part of the topological collection Multicomponent Reactions (MCRs) Towards Scaffolds with Versatile Applications; Preprint posted on ChemRxiv)

88. Substrate Promiscuity and Hyperoxidation Susceptibility as Potential Driving Forces for the Co-evolution of Prx5-Type and Prx6-Type 1-Cys Peroxiredoxin Mechanisms, L. Lang, A.-C. Wolf, M. Riedel, L. Thibol, F. Geissel, K. Feld, J. Zimmermann, B. Morgan, G. Manolikakes, M. Deponte*, ACS Catalysis2023, ASAP Article.

87. Visible-Light Induced Fixation of SO2 into Organic Molecules with Polypyridine Chromium(III) Complexes, S. Sittel, A. C. Sell, K. Hofmann, C. Wiedemann, J. P. Nau, C. Kerzig*, G. Manolikakes*, K. Heinze*, ChemCatChem2023, e202201562. (Part of the topological collection Photocatalytic Synthesis – Catalysts, Catalytic Strategies, and Mechanistic Insights)

86. A Enamide-Based Diastereoselective Synthesis of Isoindolo[2,1-a]quinolin-11(5H)-ones with Three Contiguous Stereogenic Centers, M. Halaczkiewicz, H. Kelm, G. Manolikakes, Eur. J. Org. Chem. 2023, 26, e202201318. (Preprint posted on ChemRxiv)

2022

85.  Stereoselective Synthesis of 2-Oxyenamides, S.-C. Krieg, J. Grimmer, A. M. Pick, H. Kelm, M. Breugst, G. Manolikakes, Eur. J. Org. Chem 2022, e202200772. (Preprint posted on ChemRxiv)

84.  Base-mediated C4-selective C-H-sulfonylation of Pyridine, M. Friedrich, G. Manolikakes, Eur. J. Org. Chem. 2022, e202200915. (Preprint posted on ChemRxiv)

83.  Direct C-H-Sulfonylation of 6-Membered Nitrogen-Heteroaromatics, M. Friedrich, L. Schulz, K. Hofman, R. Zangl, N. Morgner, S. Shaaban, G. Manolikakes, Tetrahedron Chem, 2022, 1, 100003. (Preprint posted on ChemRxiv)

2021

82. Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids, N. Hellmuth, C. Brat, O. Awad, S. George, A.  Kahnt, T. Bauer, H. P. Huynh Phuoc, D. Steinhilber, C. Angioni, M. Hassan, K. J. Hock, G. Manolikakes, K. Zacharowski, J. Roos, T. J. Maier, Front. Pharmacol.2021,12,  715076.

81. Palladium-Catalyzed Decarboxylative 1,2-Addition of Carboxylic Acids to Glyoxylic Acid Esters, B. Jakob, I. Slimani, A. Diehl, N. Hamdi, G. Manolikakes, Eur. J. Org. Chem.2021, 6340-6346 (Special Issue: In Memory of Klaus Hafner).

80. Recent Progress and Emerging Technologies towards a sustainable synthesis of sulfones, S. Liang, K. Hofman, M. Friedrich, J. Keller, G. Manolikakes, ChemSusChem2021, 14, 4878-4902.

79. Oxyenamides as Versatile Building Blocks for a Highly Stereoselective One-Pot Synthesis of the 1,3-Diamino-2-ol-Scaffold Containing Three Continuous Stereocenters, S.-C. Krieg, J. Grimmer, P. Kramer, M. Bolte, H. Kelm, G. Manolikakes, Angew. Chem. Int. Ed.2021, 60, 23667-23671.

78. Urea-functionalized organoseleniums compounds as promising anti-Hep2g and apoptosis-inducing agents, F. F. El-Senduny, S. M. Shabana, D. Rösel, J. Brabek, I. Althagafi, G. Angeloni, G. Manolikakes, S. Shaaban, Future Med. Chem. 2021, 13, 1655-1677.

77. Synthesis of Nitroolefins via the Direct Nitration of Alkenes, M. Hassan, C. Ndefo Nde, G. Manolikakes, SynOpen, 2021, 5, 229-231.

76.  Advances in the photochemical and electrochemical incorporation of sulfur dioxide for the synthesis of value-added compounds, S. P. Blum, K. Hofman, G. Manolikakes, S. Waldvogel, Chem. Commun.2021, 57, 8236-8249.

75. Streamlined One-Pot Synthesis of Nitro Fatty Acids, M. Hassan, S.-C. Krieg, C. Ndefo Nde, J. Roos. T. J. Maier, E. A. El Rady, M. A. Raslan, K. U. Sadek, G. Manolikakes, Eur. J. Org. Chem. 2021, 2239. (Highlighted in Chemistry Views and Org. Chem. Highlights: Carbon-Carbon Bond Construction)

74. Enhancing the Chemosensitivity of Hep2G Cells towards Cisplatin by Organoselenium Pseudopeptides, S. Shaaban, S. M. Shabana, Y. S. Al-Faiyz, G. Manolikakes, F. F. El-Senduny, Bioorg. Chem.2021, 104, 104713.

73. 1-Phosphorous-functionalized-2-(organooxy)alkenes, J. Grimmer, S.-C. Krieg, G. Manolikakes, in: Science of Synthesis Knowledge Updates 2021/1. Georg Thieme Verlag: New York (2021),p. 255.

71. 1-Nitrogen-functionalized-2-(organooxy)alkenes, J. Grimmer, S.-C. Krieg, G. Manolikakes, in: Science of Synthesis Knowledge Updates 2021/1. Georg Thieme Verlag: New York (2021), p. 237.

70. 1-(Organochalcogeno)-2-(organooxy)alkenes, J. Grimmer, S.-C. Krieg, G. Manolikakes, in: Science of Synthesis Knowledge Updates 2021/1. Georg Thieme Verlag: New York (2021), p. 217.

2020

69.The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer, Piesche M., Roos J., Kühn B., Fettel J., Hellmuth N., Brat C., Maucher I. V., Awad O., Matrone C., Comerma Steffensen S. G., Manolikakes G., Heinicke U., Zacharowski K. D., Steinhilber D., Maier T. J., Front. Pharmacol.2020, 11, 1297.

68. Palladium-Catalyzed Decarboxylative Three-Component Synthesis of α-Arylglycines: Replacing Boronic Acids with Carboxyclic Acids in the Petasis Reaction, A. M. Diehl, G. Manolikakes, ChemCatChem2020, 12, 3463-3466.

67. Recent Advances in the Synthesis and Direct Application of Sulfinate Salts, S. Liang, K. Hofman, M. Friedrich, G. Manolikakes, Eur. J. Org. Chem.2020, 4664-4676.

66. Rapid Assembly of Molecular Complexity from Simple Enamides, P. Kramer, G. Manolikakes, Synlett2020, 1027-1032 (invited Synpacts article).

65. Iron(III)-Mediated Oxysulfonylation of Enamides with Sodium and Lithium Sulfinates, P. Kramer, M. Halaczkiewicz, Y. Sun. H. Klam, G. Manolikakes, J. Org. Chem.2020, 85, 3617-3637. (Preprint deposited on ChemRxiv)

2019

64. An Enamide-Based Domino Reaction for a Highly Stereoselective Synthesis of Tetrahydropyrans P. Kramer, J. Grimmer, M. Bolte, G. Manolikakes, Angew. Chem. Int. Ed. 2019, 58, 13056-13059. Selected as Hot Paper.

63. Catalyst-free direct synthesis of β-enaminones through reaction of benzohydrazonamides with cyclic 1,3-diketones: Access to exocyclic β-enaminones, M. A.-M. Gomaa, G. Manolikakes, Y. Sun, D. K. Hassan, Synth. Commun.2019, 49, 3161-3168.

62. Manganese(III) acetate-mediated direct C(sp2)-H-sulfonylation of enamides with sodium and lithium sulfinates, P. Kramer, S.-C. Krieg, H. Kelm, G. Manolikakes, Org. Biomol. Chem.2019, 17, 5538-5544. This article is part of the themed collections Synthetic methodology in OBC and Direct C-H Functionalization in Method Development and Late-Stage Functionalization.

61. Electron diffraction tomography and X-ray powder diffraction on photoredox catalyst PDI, A. Bodach, H. Zhao, N.-W. Liu, E. Alig, G. Manolikakes, L. Fink, CrystEngComm2019, 21, 2571-2575.

2018

60. Recent Advances in the Synthesis of C–S Bonds via Metal-Catalyzed or -Mediated Functionalization of C–H Bonds, S. Liang, S. Shaaban, N.-W., K. Hofman, G. Manolikakes, G., Adv. Organomet. Chem. 2018, 69, 135-207.

59. Bi(OTf)3-catalyzed Diastereoselective One-Pot Synthesis of 1,3-Diamines with Three Continous Stereoogenic Centers, J. Halli, P. Kramer, J. Grimmer, M. Bolte, G. Manolikakes, J. Org. Chem. 2018, 83, 12077-12022.

58. Visible-light-induced 3-component synthesis of sulfonylated oxindoles via fixation of sulfur dioxide, N.-W. Liu, Z. Chen, A. Herbert, H. Ren, G. Manolikakes, Eur. J. Org. Chem. 2018, 5725-5734. 

57. Sulfonamides as Amine Component in the Petasis-Borono Mannich Reaction: A Concise Synthesis of α-Aryl- and α-Alkenylglycine Derivatives, A. M. Diehl, O. Ouadoudi, E. Andreadou, G. Manolikakes, Synthesis2018, 3936-3946. 

56. Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells, B. Kühn, C. Brat, J. Fettel, N. Hellmuth, I. V. Macher, U.  Bulut, K. J. Hock, J. Grimmer, G. Manolikakes, M. Rühl, A. Kühn, K. Zacharowski, C. Matrone, A. Urbschat, J. Roos, D. Steinhilber, T. J. Maier, Biochem. Pharmacol.2018, 155, 46-80.

55. Cytoprotective and antioxidant properties of organic selenides for the mylein-forming cells, oligodendrocytes, S. Shaaban, D. Vervandier-Fasseur, P. Andreoletti, A. Zarrouk, P. Richard, G. Manolikakes, C. Jacob, M. Cherkaoui-Malki, M.; Bioorg. Chem. 2018, 80, 43-56.

54. Visible-Light mediated 3-Component Synthesis of Sulfonylated Coumarins from Sulfur Dioxide, Z. Chen, N.-W. Liu, M. Bolte, H. Ren, G. Manolikakes, Green Chemistry2018, 20, 3059-3070:

53. Visible-Light Photoredox/Nickel Dual Catalysis for the Cross-Coupling of Sulfinic Acid Salts with Aryl Iodides, N.-W. Liu, K. Hofman, A. Herbert, G. Manolikakes, Org. Lett.2018, 20, 760-763. Among the most accessed articles in 02/2018.

52. Radicals and Sulfur Dioxide: A Versatile Combination for the Construction of Sulfonyl-Group Containing Molecules, K. Hofman, N.-W. Liu, G. Manolikakes, Chem. Eur. J.2018, 24, 11852-11863. Highlighted with a frontispiece. his article is part of a Special issue for the 7th EuCheMS Chemistry Congress and has been selected as Review Showcase.

51. Stereoselective One-Pot Synthesis of Dihydropyrimido [2,1-a]isoindole-6(2H)-ones, P. Kramer, J. Schönefeld, M. Bolte, G. Manolikakes, Org. Lett.2018, 20, 178-181.

50. Nickel-Catalyzed Synthesis of Diaryl Sulfones from Aryl Halides and Sodium Sulfinates, N.-W. Liu, S. Liang, N. Margraf, S. Shaaban, V. Luciano, M. Drost, G. Manolikakes, Eur. J. Org. Chem.2018, 1208-1210. Selected for a Cover Feature and Outstanding Organics.

2017

49. Mn(OAc)3-Mediated C-H-Sulfonylation of 1,4Dimethoxybenzenes with Sodium and Lithium Sulfinates., S. Liang, Y. Ren, G. Manolikakes, Eur. J. Org. Chem. 2017, 4117-4120. Selected for Outstanding Organics.

48. Visible-Light Photoredox-Catalyzed Aminosulfonylation of Diaryliodonium Salts with Sulfur Dioxide and Hydrazines, N.-W. Liu, S. Liang, G. Manolikakes, Adv. Synth. Cat.2017, 359, 1308-1319: Selected as Very Important Publication (VIP). Among the most accessed articles in 2017.

47. Synthesis of Sulfones via Selective C-H-Functionalization, S. Shaaban, S. Liang, N.-W. Liu, G.: Manolikakes, Org. Biomol. Chem.2017, 15, 1947-1955. 

46. Modular, Two-Step Approach for the Stereoselective Synthesis of 1,3-Diamines with Three Continuous Stereocenters, J. Halli, J. Bats, M. Bolte, G. Manolikakes, Org. Lett.2017, 19, 674-677: 

45. Bismuth- and Iron-Catalyzed Three-Component Synthesis of a-Amino Acid Derivatives: A Simple and Convenient Route to a-Arylglycines, J. Halli, A. E. Schneider, P. Kramer, A. Shemet, G. Manolikakes, Synthesis2017, 849-879. This article is part of a special section for Bürgenstock Junior Contributionsand has been highlighted in Thieme Chemistry News.

44. Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418, I. V. Maucher, M. Rühl, S. B. Kretschmer, B.; Hofmann, B. Kühn, J. Fettel, A. Vogel, K. T. Flügel, G. Manolikakes, N. Hellmuth, A.-K. Häfner, V. Golghalyani, A.-K. Ball, M. Piesche, C. Matrone, G. Geisslinger,  M. J. Parnham, M. Karas, D. Steinhilber, J. Roos, T. J. Maier,Biochem. Pharmacol.2017, 125, 55-74. 

43. Young Career Focus: Dr. Georg Manolikakes, Synform2017, 03, A53-A55.

42. Modular Regiospecific Synthesis of Nitrated Fatty Acids, K. J. Hock, J. Grimmer, D. Göbel, G. G. T. Gasaya, J. Roos, I. V. Maucher, B. Kühn, J. Fettel, T. J. Maier, G. Manolikakes, Synthesis2017, 615-636. 

41. Copper-Catalyzed Remote para-C-H Functionalization of Anilines with Sodium and Lithium Sulfinates, S. Liang, M. Bolte, G. Manolikakes, Chem. Eur. J.2017, 23, 96-100.Most accessed article in 11/2016.

2016

40. Nickel-Katalyse offenbart neue Reaktivitäten, T. Beisel, G. Manolikakes, Nachrichten aus der Chemie2016, 64, 1060-1064.

39. 2‑Photonen-Absorption auf Umwegen, N.-W. Liu, G. Manolikakes, Nachrichten aus der Chemie2016, 64, 851-854. 

38. Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Arylglycines, T. Beisel, A. M. Diehl, G. Manolikakes, Org. Lett.2016, 18, 4116-4119. This work has been highlighted in Synfacts2016, 1049.

37. Copper-Catalyzed Remote C-H Functionalization of 8-Aminoquinolines with Sodium and Lithium Sulfinates, S. Liang, G. Manolikakes, Adv. Synth. Cat.2016, 358, 2371-2378. This article is part of a special issue on Base Metal Catalysis.

36. Totalsynthese von Strictamin, J. Grimmer, G. Manolikakes,  Nachrichten aus der Chemie2016, 64, 747-750.

35. Recent Developments in the Synthesis of Sulfones, N.-W. Liu, S. Liang, G. Manolikakes, Synthesis2016, 1939-1970.Most cited article published in Synthesis in 2016.

34. Katalytische C-H-Aktivierungen mit unedlen Übergangsmetallen, A. M. Diehl, G. Manolikakes, Nachrichten aus der Chemie2016, 64, 519-522. 

33. Wenn Löcher Bindungen stärken: die Halogenbrücken, J. Halli, G. Manolikakes, Nachrichten aus der Chemie 2016, 64, 131-134.

32. 3‑Component synthesis of alpha-substituted sulfonamides via Brønsted acid-catalyzed C(sp3)–H bond functionalization of 2-alkylazaarenes, T. Beisel, J. Kirchner, T. Kaehler, J. Knauer, Y. Soltani, G. Manolikakes, Org. Biomol. Chem. 2016,14, 5525-5528. This article is part of the themed collection New Talent.

31. Copper-Mediated Sulfonylation of C(sp2)-H-Bonds with Sodium and Lithium Sulfinates, S. Liang, N.-W. Liu, G. Manolikakes, G., Adv. Synth. Cat.2016, 358, 159-163. This work has been highlighted in Synfacts 2016, 297.

30. A Palladium-Catalyzed Three-Component Synthesis of Arylmethylsulfonamides, T. Beisel, G. Manolikakes, Synthesis2016, 379-386. 

2015

29. Nickel-catalyzed Synthesis of Enamides and Enecarbamates via Isomerization of Allylamides and Allylcarbamates, J. Halli, P. Kramer,M. Bechthold, G. Manolikakes,  Adv. Synt. Cat. 2015, 357, 3321-3324.  

28. Synthesis of N-Acyl-N,O-acetals from Aldehydes, Amides and Alcohols, J. Halli, K. Hofman, T. Beisel, G. Manolikakes, Eur. J. Org. Chem.20154624-4627

27. Palladium-Catalyzed Enantioselective Three-Component Synthesis of α-Substituted Amines, T. Beisel, G. Manolikakes, Org. Lett.2015, 17, 3162-3165. This work has been highlighted in: Synfacts2015, 827.

26. Bi(OTf)3-Catalyzed Multicomponent α-Amidoalkylation Reactions, A. E. Schneider, G. Manolikakes, J. Org. Chem. 2015, 80, 6193-6212. This work has been highlighted in: Org. Process Res. Dev. 2015, 19, 769.

25. One-Pot Synthesis of Aryl Sulfones from Organometallic Reagents and Iodonium Salts, N. Margraf, G. Manolikakes, J. Org. Chem. 2015, 80, 2582-2600: This work has been highlighted in: Synfacts 2015, 539.

2014

24. Coupling Reactions Between sp3 and sp2 Carbon Centers, G. Manolikakes, in: Comprehensive Organic Synthesis II, Vol. 3 Carbon-Carbon-Bond Formation. Eds. P. Knochel, G. A. Molander, Elsevier (2014), Vol. 3,  p. 392.

23. Bi(OTf)3-Catalyzed Three-Component Synthesis of α-Amino Acid Derivatives, A. E. Schneider, T. Beisel, A. Shemet, G. Manolikakes, Org. Biomol. Chem. 2014, 12, 2356-2359. 

2013

22. A Lewis Acid Palladium(II)-Catalyzed Three-Component Synthesis of α-Substituted Amides, T. Beisel, G. Manolikakes, Org. Lett.2013, 15, 6046-6049. 

21. Iron-Catalyzed Three-Component Synthesis of α-Amino Acid Derivatives, J. Halli, G. Manolikakes, Eur. J. Org. Chem. 2013, 2013, 7471-7475. This work has been highlighted in: Org. Process Res. Dev.2013, 17, 1464.

20. Arylation of Lithium Sulfinates with Diaryliodonium Salts: A Direct and Versatile Access to Arylsulfones, N. Umierski, G. Manolikakes, Org. Lett.2013, 15, 4972-4975. This work has been highlighted in: Synfacts2013, 1326.

19. Bi(OTf)3-Catalyzed Three-Component Synthesis of Amidomethylarenes and -Heteroarenes, A. E. Schneider, G. Manolikakes, Synlett2013, 2057-2060. 

18. Metal-Free Synthesis of Diaryl Sulfones from Arylsulfinic Acid Salts and Diaryliodonium Salts, N. Umierski, G. Manolikakes, Org. Lett. 2013, 15, 188-191.

 

2012

17. Transition-Metal-Catalyzed Carbon-Carbon-Bond Formation with Organolithiums, G. Manolikakes, in: Science of Synthesis Knowledge Updates 2012/1. Georg Thieme Verlag: New York (2012), p. 215.

2011

16. Functionalization of Heterocyclic Compounds using Polyfunctional Magnesium and Zinc Reagents, P. Knochel, M. A. Schade, S. Bernhardt, G. Manolikakes, A. Metzger, F. M. Piller, C. J. Rohbogner, M. Mosrin,  Beilstein J. Org. Chem.2011, 7, 1261-1277.This work has been highlighted in: Org. Process. Res. Dev.2012, 16, 180.

15. Preparation of Solid Salt-Stabilized Organozinc Compounds and their Application to Cross-Coupling and Carbonyl Addition Reactions, S. Bernhardt, G. Manolikakes, T. Kunz, P. Knochel, Angew. Chem. Int. Ed. 2011, 50, 9205-9209. 

14. Scalable Synthesis of Cortistatin A and Related Structures, J. Shi, G. Manolikakes, C.-H. Yeh, C. A. Guerrero, R. A. Shenvi, H. Shigehisa, P. S. Baran,  J. Am. Chem. Soc. 2011, 133, 8014-8027.

2010

13. Preparation of Primary Amides from Functionalized Organozinc Halides, M. A. Schade, G. Manolikakes, P. Knochel, Org. Lett. 2010, 12, 3648-3650.

12. MgCl2-Enhanced Reactivity of Functionalized Organozincs Towards Their Addition to Aldehydes, Ketones and Carbon Dioxide, A. Metzger, S. Bernhardt, G. Manolikakes, P. Knochel,  Angew. Chem. Int. Ed. 2010, 49, 4665-4668.

11. Structure-Reactivity Relationships in Negishi Cross-Coupling Reactions, Z. Dong, G. Manolikakes, L. Shi, P. Knochel, H. Mayr, H., Chem. Eur. J.2010, 16, 248-253. 

2009

10. Negishi Cross-Couplings Compatible with Unprotected Amide Functions, G. Manolikakes, Z. Dong, H. Mayr, J. Li, P. Knochel, Chem. Eur. J.2009, 15, 1324-1328.

9. Palladium-Catalyzed Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Hydrogen Atoms with Organozinc Reagents, Z. Dong, G. Manolikakes, J. Li, P. Knochel, Synthesis, 2009, 681-686 (Practical Synthetic Procedure).

8. Radical Catalysis of Kumada Cross-Coupling Reactions Using Functionalized Grignard Reagents, G. Manolikakes, P. Knochel, P., Angew. Chem. Int. Ed.2009, 48, 205-209. This work has been highlighted in: Synform2009, 4.

7. Palladium- and Nickel-Catalyzed Cross-Couplings of Unsaturated Halides Bearing Relatively Acidic Protons with Organozinc Reagents, G. Manolikakes, C. Munoz Hernandez, M. A. Schade, A. Metzger, P. Knochel, P., J. Org. Chem.2008, 73, 8422-8436. This work has been highlighted in: Org. Process. Res. Dev.2009, 13, 2 and Synfacts2009, 307 (Synfact of the Month).

2008

6. A General Preparation of Polyfunctional Benzylic Zinc Organometallic Compounds, A. Metzger, A.; Schade, M. A.;  Manolikakes, G.; Knochel, P., Chem. Asian. J.2008, 3, 1678-1691.

4. An Efficient Silane-Promoted Nickel-Catalyzed Amination of Aryl and Heteroaryl Chlorides, G. Manolikakes, A. Gavryushin, P. Knochel, J. Org. Chem.2008, 73, 1429-1434.

2007

3. Nickel-Catalyzed Cross-Coupling Reactions of Aryltitanium(IV) Alkoxides with Aryl Halides, G. Manolikakes, N. Dastbaraverdeh, P. Knochel, Synlett2007, 13, 2077-2080: 

2006

 2. An Efficient Negishi Cross-Coupling Reaction Catalyzed by Nickel(II) and Diethyl Phosphite, A. Gavryushin, C. Kofink, G. Manolikakes, P. Knochel, Tetrahedron2006, 62, 7521-7533.

2005

1. Efficient Cross-Coupling of Functionalized Arylzinc Halides Catalyzed by a Nickel Chloride-Diethyl Phosphite System, A. Gavryushin, C. Kofink, G. Manolikakes, P. Knochel, Org. Lett.2005, 7, 4871-4874.

Patents

 2. Organozinc complexes and processes for making and using the same, P. Knochel, S. Bernhardt, G. Manolikakes, WO2012085168A1, 2011.

1. Nickel- and iron catalyzed carbon-carbon bond forming reactions of organozinc compounds with electrophiles, P. Knochel, A. Gavryushin, G. Manolikakes, C. Kofink, WO2007031511A1, 2005.

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