Genotoxicity of glycidamide in comparison to (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide
and alpha-acetoxy-N-nitroso-diethanolamine in human blood and V79-cells
Thielen S., Baum M., Hoffmann M., Loeppky R.N., Eisenbrand G. Molecular Nutrition and Food Research2005, accepted
Modulation of oxidative celo damage by polyphenolic apple juice
extracts and major consitutents in human colon cells
Schaefer S., Baum M., Eisenbrand G., Dietrich H., Will F., Janzowski
C. Molecular Nutrition and Food Research2005,
submitted
Molecular targets of indirubins
Jakobs S., Merz K.-H., Vatter S., Eisenbrand G. International
Journal of Clinical Pharmacology and Therapeutics 2005,
43 (12), 592-594
Searching for cellular targets of novel pteridines downstream of
cAMP PDE inhibition
Vatter S., Merz K.-H., Eisenbrand G. International Journal
of Clinical Pharmacology and Therapeutics 2005, 43
(12), 607-608
Natural flavonoids are potent inhibitors of glycogen phosphorylase
Jakobs S., Fridrich D., Hofem S., Pahlke G., Eisenbrand G. Molecular
Nutrition and Food Research2005, in press
Ochratoxin A induces oxidative DNA damage in liver and kidney after
oral dosing to rats
Kamp H.G., Eisenbrand G., Janzowski C., Kiossev J., Latendresse J.R.,
Schlatter J., Turesky R.J. Molecular Nutrition and Food Research2005, 49, 1160-1167
Indirubin-3’-Aminooxy-Acetate inhibtis Glycogen Phosphorylase by
Binding at the Inhibitor and the Allosteric Site. Broad Specificities
of the Two Sites
Kosmopoulou M.N., Leonidas D.D., Chrysina E.D., Eisenbrand G., Oikonomakos
N.G. Letters in Drug Design & Discovery 2005,
2, 377-390
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis
in human cancer cells
Nam S., Buettner R., Turkson J., Kim D., Cheng J.Q., Muehlbeyer S.,
Hippe F., Vatter S., Merz K.-H., Eisenbrand G., Jove R. PNAS2005, 102 (17), 5998-6003
Differential phosphodiesterase expression and cytosolic Ca2+ in
human CNS tumour cells and in non-malignant and malignant cells of
rat origin.
Vatter S., Pahlke G., Deitmer J.W., Eisenbrand G. Journal
of Neurochemistry 2005, 95, 321-329
From the insoluble dye indirubin towards highly active, soluble
CDK2-inhibitors.
Jautelat R., Brumby T., Schäfer M., Briem H., Eisenbrand G., Schwahn
S., Krüger M., Lücking U., Prien O., Siemeister G. ChemBioChem2005, 6 (3), 531-540
Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity
and apoptosis in mammalian cell lines and primary cells.
Kamp H.G., Eisenbrand G., Schlatter J., Würth K., Janzowski C. Toxicology2005, 206, 413-425
Inhibition of GSK3ß by indirubins restores HIF-i? accumulation under
prolonged periods of hypoxia/anoxia.
Schnitzer S.E., Schmid T., Zhou J., Eisenbrand G., Brüne B. FEBS
Letters2005, 579, 529-533
Criteria for the evaluation of functional foods
Eisenbrand G. Molecular Nutrition and Food Research2004, 48, 541-544
Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood
Baum M., Fauth E., Fritzen S., Hermann A., Mertes P., Merz K.-H., Rudolphi M., Zankl H., Eisenbrand G. Toxicology2004, 580, 61-69
Novel indirubin derivatives, promising antitumor agents inhibiting
cyclin-dependent kinases.
Merz K.H., Schwahn S., Hippe F., Mühlbeyer S., Jakobs S., Eisenbrand G. International Journal of Clinical Pharmacology and Therapeutics2004, 42 (11), 656-658
Effects of hemodialysis, dialyser type and iron infusion on oxidative
stress in uremic patients.
Müller C., Eisenbrand G., Gradinger M., Rath T., Albert F.W.,
Vienken J., Singh R., Farmer P.B., Stockis J.-P., Janzowski C. Free Radical Research2004, 38 (10), 1093-1100
Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules
with their origin in traditional Chinese phytomedicine.
Eisenbrand G., Hippe F., Jakobs S., Mühlbeyer S. Journal of Cancer Research and Clinical Oncology2004, 130, 627-635
Inhibition of Leishmania mexicana CRK3 Cyclin-Dependent Kinase:
Chemical Library Screen and Antileishmanial Activity.
Grant K.M., Dunion M.H., Yardley V., Skaltsounis A.-L., Marko D.,
Eisenbrand G., Croft S.L., Meijer L., Mottram J.C. Antimicrobial Agents and Chemotherapy2004, 48 (8), 3033-3042
Sensitive in vitro test systems to determine androgenic/antiandrogenic
activity
Guth S.E., Böhm S., Mu&sßler B.H., Eisenbrand G. Mol. Nutr. Food Res.2004, 48 (4) , 282-291
Binding of the potential antitumour agent indirubin-5-sulphonate at
the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison
with ligand binding to pCDK2-cyclin A complex.
Kosmopoulou M.N., Leonidas D.D., Chrysina E.D., Bischler N., Eisenbrand G.,
Sakarellos C.E., Pauptit R., Oikonomakos N.G. Eur. J. Biochem., FEBS2004, 271, 2280-2290
Alpha, beta-unsaturated carbonyl compounds: induction of oxidative
DNA damage in mammalian cells
C. Janzowski, V. Glaab, C. Müller, U. Strässer, H.G. Kamp,
G. Eisenbrand Mutagenesis2003, 18 (5), 465-470
Synthesis of N-Acetyl-S-(3-coumarinyl)-cysteine Methyl Ester and
HPLC Analysis of Urinary Coumarin Metabolites
Eisenbrand G., Michael Otteneder, W.C. Tang Toxicology2003, 190, 249-258
Mutagenic and cytotoxic effectiveness of diisopropyl xanthogen polysulphide
in human lymphocyte cultures.
V. Zensen, T.M. Ali, M. Kuproth, H. Zankl, C. Janzowski, G. Esenbrand Mutat Res2003, 535, 161-170
Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine
in membrane structures impeding the inhibition of cytosolic cyclic
AMP-specific phosphodiesterase
Doris Marko, Karl-Heinz Merz, Claudia Kunz, Anja Müller, Nadya Tarasova,
Gerhard Eisenbrand Biochemical Pharmacology2002,
63, 669-676
7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent
inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein
binding to the CRE consensus sequence in human tumour cells
Barbara Wagner, Sandra Jakobs, Michael Habermeyer, Frankie Hippe,
Yoon Sang Cho-Chung, Gerhard Eisenbrand, Doris Marko Biochemical
Pharmacology2002, 63, 659-668
Mutagenic and cytotoxic effectiveness of zinc dimethyl and zinc
diidononyldithiocarbamte in human lymphocyte cultures
V. Zensen, E. Fauth, H. Zankl, C. Janzowski, G. Eisenbrand Mutation
Research2001, 497, 89-99
DNA damaging potential and glutathione depletion of 2-cyclohexene-1-one
in mammalian cells, compared to food relevant 2-alkenals
Volker Glaab, Andrew R. Collins, Gerhard Eisenbrand, Christine Janzowski Mutation Research2001, 497, 185-197
Lycobetaine acts as a selective topoisomerase IIbeta poison and
inhibits the growth of human tumor cells.
Hans Ullrich Barthelems, Ellen Niederberger, Thomas Roth, Kerstin
Schulte, Wei Ci Tang, Fritz Boege, Heinz-H. Fiebig, Gerhard Eisenbrand,
Doris Marko British Journal of Cancer2001, 85
(10), 1585-1591
Inhibitor Binding to Active and Inactive CDK2: The Crystal Structure
of CDK2-Cyclin A/Indirubin-5-Sulphona
Thomas G. Davies, Paul Tunnah, Laurent Meijer, Doris Marko, Gerhard
Eisenbrand, Jane A. Endicott, Martin E.M. Noble Structure2001, Vol. 9, 389-397
Anti-mitotic properties of indirubin-3'-monoxime, a CDK/GSK-3 inhibiotr:
induction of endoreplicatin following prophase arrest
E. Damiens, B. Baratte, D. Marie, G. Eisenbrand, L. Meijer Oncogene2001, 20, 3786-3797
Metabolic Activation of Benzo(c)phenanthrene by Cytochrome P450
Enzymes in Human Liver and Lung
M. Baum, S. Amion, F.P. Guengerich, S.S. Hecht, W. Köhl, G. Eisenbrand Chemical Research in Toxicology2001, Vol. 14,
Number 6, 686-693
Indirubins inhibit glycogen synthase kinase–3beta and CDK/p25,
two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s
disease – A property common to most CDK inhibitors?
S. Leclerc, M. Garnier, R. Hoessel, D. Marko, J.A. Bibb, G.L. Snyder,
P. Greengard, J. Biernat, E.-M. Mandelkow, G. Eisenbrand, L. Meijer Journal of Biological Chemistry2001, 276 (1),
251-260
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives
in human tumor cells
D. Marko, S. Schätzle, A Friedel, E. Niederberger, A Genzlinger, H.
Zankl, L Meijer, G. Eisenbrand British Journal of Cancer 2001,
84 (2), 283-289
Kombinationswirkungen hormonartig wirkender Chemikalien
G.Eisenbrand, B. Mußler, G. Degen Arbeitsphysiologie heute
2000, 2, 27-39
5-Hydroxymethylfurfural: Assessment of mutagenicity, DNA damaging
potetial and reactivity towards cellular glutathione
C. Janzowski, V. Glaab, E. Samimi, J. Schlatter, G. Eisenbrand Food and Chemical Toxicology 2000, 38, 801-809
Cyclic 3’,5’-Nucleotide Phosphodiesterases: Potential
Targets for Anticancer Therapy
D. Marko, G. Pahlke, K.-H. Merz, G. Eisenbrand Chem. Res.
Tox. 2000, 13, 944-948
Estimation of Human Exposure to Styrene and Ethylbenzene
W. Tang, I. Hemm G. Eisenbrand Toxicology 2000,
144, 39-50
Indirubin, the active constituent of a Chinese antileukeamia medicin,
inhibits cyclin-depentent kinases
R. Hössel, S. Leclerc, J.A. Endicott, M.E.M.Nobel, A. Lawrie, P Tunnah,
M Leost, E. Damiens, D. Marie, D. Marko, E. Niederberger, W. Tang,
G. Eisenbrand, L. Meijer Nature Cell Biology1999,
Vol. 1, No. 1, 66-67
Preclinical activity of 17ß-[N-[N‘-(2-chloroethyl)-N‘-nitrosocarbamoyl]-L-alanyl]-5alpha-dihydrotestosterone
(E91) against tumour colony forming units and haematopotetic progenitor
cells
P. Rank, R. Peter, H. Depenbrock, G. Eisenbrand, P. Schmid, H. Pitzl,
A.R. Hanauske Europ. Journal of Cancer 1999,
Vol.35, No.6, 1009-1013
Probing the mechanism of the carcinogenic activation of N-nitrosodiethanolamine
with deuterium isotope effects: in vivo induction of DNA single strand
breaks and related in vitro assays
R.N. Loeppky, A. Fuchs, C. Janzowski, C. Humberd, P. Gölzer, H. Scheider,
G. Eisenbrand Chem. Res.Toxicol. 1998, 11,
1556-1566
Synthesis of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine
and novel derivatives free of positional isomers. Potent inhibitors
of cAMP-specific phosphodiesterase and of malignant tumor cell growth
K.-H. Merz, D. Marko, T. Regiert, G. Reiss, W. Frank, G. Eisenbrand J. Med. Chem. 1998, 41 (24), 4733-4743
Novel steroid-linked conjugates of 17ß-[N-[N‘-(2-chloroethyl)-N‘-nitroso]
carbamoyl]amino acids and their antineoplastic activity against Noble
Nb prostate carcinoma model in rats
W. Tang, M.R. Schneider, G. Eisenbrand Anti-Cancer Drug Design
1998, 13, 815-824
Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant
murine carcinoma cells overexpressing PDE activity in comparison to
their non malignant counterparts
D. Marko, K Romanakis, H. Zankl, G. Fürstenberger, B. Steinbauer,
G. Eisenbrand Cell Biochemistry and Biophysics 1998,
28, 75-101
239
Mutagene und kanzerogene Inhaltsstoffe offizineller chinesischer
Heilpflanzen
G. Eisenbrand, W. Tang Zeitschrift für Phytotherapie 1998,
19, 39-42
Potential nitrosamine formation and its prevention during biological
denitrification of red beet juice
E. Kolb, M. Haug, C. Janzowski, A. Vetter, G. Eisenbrand Food
Chem. Toxicol. 1997, 35, 219-224
Genotoxic effects of 2-trans-hexenal in human buccal mucosa
cells in vivo
U. Dittberner, Beate Schmetzer, P. Gölzer, G. Eisenbrand, H. Zankl Mut. Res. 1997, 390, 161-165
N-nitroso compounds in cosmetics, household commodities
and cutting fluids
G. Eisenbrand, A. Fuchs. W. Köhl European Journal of Cancer
Prevention 1996, 5 (supplement 1), 41-46
An approach towards more selective anticancer agents
G. Eisenbrand, S. Lauck-Birkel, W.C. Tang Synthesis 1996,
10, 1246-1258
(E)-2-Hexenal-induced DNA damage and formation of cyclic 1,N2-(1,3-propano)-2'-deoxoguanosine
adducts in mammalian cells
P. Gölzer, C. Janzowski, B.L. Pool-Zobel, G. Eisenbrand Chem.
Res. Toxicol 1996, 9, 1207 - 1213
Untersuchungen zur Nitritbildung und zum Nitrosierungspotential
bei der heterotrophen biologischen Denitrifizierung von Trinkwasser
unter Laborbedingungen
S. Kevekordes, M. Urban, W. Steffens, Ch. Janzowski, G. Eisenbrand,
H. Dunkelberg Zbl. Hyg. 1996, 198, 462-472
Synthesis of novel androgen-linked phosphoramide mustard prodrugs
and growth-inhibitory activity in human breast cancer cells
T. Roth, W. Tang, G. Eisenbrand Anti-Cancer Drug Design 1995,
10, 655-666
Genotoxic effects of the alpha, beta-unsaturated aldehydes 2-trans-butenal,
2-trans-hexenal and 2-trans-, 6-cis-nonadienal
U. Dittberner, G. Eisenbrand, H. Zankl Mutation Research 1995,
335, 259-265
Stable expression of human cytochrome P450 2E1 in V29 chinese hamster
cells
W.A. Schmalix, M. Barrenscheen, R. Landsiedel, C. Janzowski, G. Eisenbrand,
F. Gonzalez, E. Eliasson, M. Ingelmann-Sundberg, M. Perchermeier,
H. Greim, J. Doehmer Eur. J. Pharmacol. Environ. Toxicol. Pharmacol.
Section 1995, 293, 123-131
The influence of glutathione and detoxifying enzymes on DNA damage
induced by 2-alkenals in primary rat hepatocytes and human lymphoblastoid
cells
G . Eisenbrand, J. Schumacher, P. Gölzer Chem. Res. Toxicol.
1995, 8, 40-46